Francis G. Spinale

This study uses speckle-tracking echocardiography to monitor LV remodeling in porcine models of pressure overload, exercise, and their combination, finding divergent effects on myocardial and chamber stiffness.

This study examines sex-specific effects of chronic unpredictable stress on mitochondrial function in the HPA axis of mice, finding reduced mitochondrial respiration in females and increased complex II protein in males.

This paper develops anti-FAP antibody-modified nanoparticles that target cardiac fibrosis in a rat model, reducing talabostat dose by 400,000-fold and reversing fibrosis and dysfunction.