Ryan Cummings

OmniSplice detects non-canonical splicing events from RNA-seq by analyzing reads overlapping annotated exon ends without assuming predefined splice-junction structures, revealing widespread splicing defects in Drosophila and mouse mutants.

The paper shows that chromocenter formation in Drosophila depends on interactions between satellite DNA-binding proteins D1 and Prod, which package chromosomes into a single nucleus.