Author

Sven A. Miller

Fox Chase Cancer CenterORCID 0000-0001-7295-5592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

John KaranicolasiD· 2 shared Alexandra IndegliaiD· 1 shared Alison Schwartz LevineiD· 1 shared Anne NaumeriD· 1 shared Benjamin E. BlassiD· 1 shared Caitlin Orr· 1 shared Christopher S Parry· 1 shared Elena Bondarenko· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

John KaranicolasORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 29, 2026

Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

Mariam Ahmed Fouad, Christopher S Parry, Sven A. Miller…·John Karanicolas

The paper identifies small molecules that stabilize and restore function to missense-mutated VHL proteins in kidney cancer cells.

DOI 10.64898/2026.01.02.697373

humanproteomics

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Cancer BiologyMolecular Cancer ResearchPeer-reviewedMay 18, 2026

Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis

Renyta Moses, Alexandra Indeglia, Alison Schwartz Levine…·Kara N. Maxwell

This study shows that p53 variants with R181 mutations retain mitochondrial apoptosis function but lose DNA binding cooperativity, leading to reduced cancer risk.

1 citation

humanDNA methylation

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