Peter J. Tonge

The paper analyzes 4,311 protein-small-molecule interactions to show that binding kinetics are mainly controlled by protein dynamics, not ligand structure.

This paper shows ganfeborole is a potent time-dependent inhibitor of M. tuberculosis LeuRS with a long post-antibiotic effect, but not effective against E. coli despite inhibiting its LeuRS.

This paper identifies genes that enhance the post-antibiotic effect (PAE) in E. coli using a high-throughput screen of deletion strains, revealing that rfaE deletion increases PAE by stabilizing LpxC.