Author

Thomas W. Burke

Duke UniversityORCID 0000-0003-0592-5822Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Genetic & Genomic Medicine· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Assay:DNA methylation· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

Christopher W. WoodsiD· 6 shared Micah T. McClainiD· 6 shared Xiling SheniD· 4 shared Bei WeiiD· 3 shared Elizabeth PetzoldiD· 3 shared Emily R. KoiD· 3 shared Joseph R. EckeriD· 3 shared Manoj HariharaniD· 3 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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6 shared papersGenomics

Christopher W. WoodsORCID

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6 papers

Recent·Most cited

GenomicsNature GeneticsPeer-reviewedJan 27, 2026

Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome

Wenliang Wang, Manoj Hariharan, Wubin Ding…·Joseph R. Ecker

This study identifies how genetic and environmental factors shape the human immune cell epigenome through differential methylation and chromatin accessibility changes.

11 citationstop 1%

humanDNA methylation

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ImmunologyCell ReportsPeer-reviewedSep 17, 2025

Innate immune epigenomic landscape following controlled human influenza virus infection

William Thistlethwaite, Sindhu Vangeti, Wan-Sze Cheng…·Stuart C. Sealfon

The paper analyzes the epigenomic changes in innate immune cells after influenza virus infection and finds coordinated rewiring of the epigenetic landscape.

5 citations

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintSep 9, 2025

Dissecting epigenome dynamics in human immune cells upon viral and chemical exposure by multimodal single-cell profiling

Irem B. Gündüz, Bei Wei, Derek C. Chen…·William James Greenleaf

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

1 citation

humanscATAC-seq

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GeneticsCell GenomicsPeer-reviewedNov 1, 2022

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus

Benjamin H. Schott, Liuyang Wang, Xinyu Zhu…·Dennis C. Ko

The paper identifies a nonsynonymous ERAP1 variant associated with increased susceptibility to influenza virus using scHi-HOST, a single-cell method for genetic susceptibility testing.

12 citations

humanscRNA-seq

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Genetic & Genomic MedicineGenome MedicinePeer-reviewedMay 17, 2021

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

Liuyang Wang, Thomas J. Balmat, Alejandro L. Antonia…·Dennis C. Ko

The paper connects genetic architecture of human diseases with molecular phenotypes to uncover mechanisms of COVID-19 susceptibility.

86 citationstop 1%

humanGWAS summary statistics

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GenomicsbioRxivPreprintDec 4, 2020

Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity

Nicholas S. Giroux, Shengli Ding, Micah T. McClain…·Xiling Shen

Chromatin accessibility in immune cells from COVID-19 subjects is remodeled prior to seroconversion to reflect disease severity.

9 citations

humanATAC-seq

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