Xiling Shen

Biological rationales from language models enable leakage-resistant forecasts of target-indication success

PRIORITI uses language models to predict target-indication success in drug discovery, achieving high accuracy and robustness across different benchmarks.

Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome

This study identifies how genetic and environmental factors shape the human immune cell epigenome through differential methylation and chromatin accessibility changes.

cloneXplorer: A high-throughput clone discovery platform based on conical microwell arrays

The paper introduces cloneXplorer, a platform for generating antigen-specific T cell clones from peripheral blood using conical microwell arrays, and demonstrates its ability to identify and isolate functionally defined T cells.

Dissecting epigenome dynamics in human immune cells upon viral and chemical exposure by multimodal single-cell profiling

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

The paper connects genetic architecture of human diseases with molecular phenotypes to uncover mechanisms of COVID-19 susceptibility.

Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity

Chromatin accessibility in immune cells from COVID-19 subjects is remodeled prior to seroconversion to reflect disease severity.