Manoj Hariharan

A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia

This paper creates a multimodal single-cell atlas of the human basal ganglia, revealing epigenomic and 3D genome features across cell types and linking them to disease-associated genetic risk.

Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome

This study identifies how genetic and environmental factors shape the human immune cell epigenome through differential methylation and chromatin accessibility changes.

Innate immune epigenomic landscape following controlled human influenza virus infection

The paper analyzes the epigenomic changes in innate immune cells after influenza virus infection and finds coordinated rewiring of the epigenetic landscape.

Dissecting epigenome dynamics in human immune cells upon viral and chemical exposure by multimodal single-cell profiling

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

DNA Methylation Dynamics of Dose-dependent Acute Exercise, Training Adaptation, and Detraining

This study examines DNA methylation changes in blood and muscle across different training programs and timepoints, identifying DMRs linked to exercise adaptation, sex, and physiological functions.

Comprehensive Guide of Epigenetics and Transcriptomics Data Quality Control

This paper provides a comprehensive guide for quality control metrics and mitigation strategies for 11 epigenetics and transcriptomics assays to improve exposure signature discovery.

Spatiotemporal DNA Methylome Dynamics of the Developing Mammalian Fetus

The paper maps DNA methylation changes across 12 mouse tissues at 8 developmental stages, identifying methylation variant regions and tissue-specific enhancers linked to human genetic diseases.