Mirella Dottori

This paper establishes that FRDA autonomic neurons are hyperexcitable and exhibit mitochondrial dysfunction using iPSC-derived models.

This paper develops a differentiation protocol to generate human hippocampal neurons and astrocytes in vitro, demonstrating long-term viability and electrophysiological complexity.

This study uses iPSCs from FRDA patients to model cardiac dysfunction, finding transcriptional dysregulation and phenotypes like increased cell size and mitochondrial stress.

This paper identifies cell-type-specific transcriptional biomarkers in Friedreich ataxia through meta-analysis of bulk RNA-seq datasets and develops an interactive transcriptomic atlas.

This study examines the effects of sertraline and voluntary exercise during pregnancy on maternal behavior and litter characteristics in rats, finding exercise reduces anxiety-like behaviors and increases DNA methylation markers, while sertraline has limited effects.

This study optimizes in vitro neuronal microenvironments to reduce phototoxicity by testing culture conditions and imaging protocols over 33 days.

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

The paper investigates REST and RCOR gene expression in human neurons and astrocytes using 2D and 3D stem cell models, finding cell-type-specific expression patterns.

This study generates human proprioceptor and low-threshold mechanoreceptor neurons from pluripotent stem cells and characterizes their molecular and functional properties.

This study identifies Elkin1 as a novel mechanically-activated ion channel essential for touch and pain sensation, independent of Piezo2.