Shiang Yong Lim

Autonomic neurons are intrinsically hyperexcitable in a Friedreich ataxia iPSC model

This paper establishes that FRDA autonomic neurons are hyperexcitable and exhibit mitochondrial dysfunction using iPSC-derived models.

An integrated cardiac microtissue proteome map extends therapeutic remodelling by nanovesicles

The paper develops a human cardiac microtissue model to study ischemia-reperfusion injury and shows that nanovesicles improve cardiomyocyte survival and function through proteomic changes.

Frataxin deficiency drives cardiac dysfunction and transcriptional dysregulation in Friedreich ataxia iPSC model

This study uses iPSCs from FRDA patients to model cardiac dysfunction, finding transcriptional dysregulation and phenotypes like increased cell size and mitochondrial stress.

Friedreich ataxia transcriptomic dysregulation and identification of cell type-specific biomarkers: A systematic review and meta-analysis

This paper identifies cell-type-specific transcriptional biomarkers in Friedreich ataxia through meta-analysis of bulk RNA-seq datasets and develops an interactive transcriptomic atlas.

DRP1 inhibition confers cardioprotection against doxorubicin while preserving anticancer efficacy

This paper shows DRP1 inhibition reduces doxorubicin-induced cardiotoxicity while maintaining its anticancer effects in multiple cancer models.

Device encapsulated MSCs for adaptive secretome therapy to effectively target ischaemic heart injury

This paper develops a device-encapsulated MSC system for sustained secretome delivery to treat ischaemic heart injury, showing improved cardiac function and reduced remodelling in rats.

Long-read sequencing-based atlas of tissue-specific expression of Drp1 transcript variants

The paper uses long-read sequencing to map Drp1 transcript variants in human and mouse tissues, revealing tissue-specific expression and isoform-dependent mitochondrial fission activity.

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

This study shows that knocking out POLDIP2 in human RPE cells reduces mitochondrial superoxide levels, linking POLDIP2 to oxidative stress in AMD.

Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma

This study uses iPSC-derived retinal organoids to identify retinal ganglion cell-specific expression quantitative trait loci associated with primary open-angle glaucoma.

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

A simple cloning-free method to efficiently induce gene expression using CRISPR/Cas9

This paper introduces a cloning-free CRISPR/Cas9 method to induce gene expression, showing efficient activation of neural development genes in human cells.