Author

Jane A. Leopold

Brigham and Women's HospitalORCID 0000-0003-0598-8882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metabolomics· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anna Ryan HemnesiD· 1 shared Aparna BalasubramanianiD· 1 shared Bradley M. WertheimiD· 1 shared Catherine E. SimpsoniD· 1 shared Clary B. ClishiD· 1 shared Darin T. RoseniD· 1 shared Elena AronsiD· 1 shared Erika B. RosenzweigiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Anna Ryan HemnesORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJun 22, 2026

Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension

Ivor Clinton, Julie C. Coursen, Darin T. Rosen…·PVDOMICS Study Group

The paper identifies metabolic modules in PAH patients linked to RV-PV function using WGCNA and validates findings in independent cohorts.

DOI 10.64898/2026.06.16.732773

humanmetabolomics

𝕏 PostBluesky

Cell BiologyNature MetabolismPeer-reviewedOct 29, 2024

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells

Wusheng Xiao, Nishith M. Shrimali, Niv Vigder…·Joseph Loscalzo

This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.

26 citations

𝕏 PostBluesky