Cell BiologyNature MetabolismPeer-reviewed
Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells
Wusheng Xiao, Nishith M. Shrimali, Niv Vigder…·Joseph Loscalzo
This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.