Eric Cascalès

This study characterizes TmeAIEC, a T6SS effector from AIEC that disrupts bacterial membranes, and identifies its immunity protein TmiAIEC and key determinants for its activity.

This study shows that type 1 fimbriae and adhesins promote microcolony formation, shielding bacteria from short-range contact-dependent weapons and maintaining phenotypic heterogeneity.

The paper identifies a new T6SS effector from Pluralibacter gergoviae that depletes NAD and NADP, defining a new clade of NAD(P) glycohydrolases called Tne5.

This paper identifies a bacterial toxin domain with a human CD38-like fold that hydrolyzes NAD+ and NADP+, inhibiting bacterial and eukaryotic growth.

This study shows that Enteroaggregative E. coli exhibits T6SS phenotypic heterogeneity, enabling a trade-off between antibacterial activity and resistance in mixed microbial environments.

This study uses experimental evolution to show that T6SS activity is lost in EAEC when grown with immune cells, identifying mutations and a novel RfaH-dependent regulatory mechanism.