Widespread repurposing of the human CD38 ADP-ribosyl cyclase fold for toxicity in antibacterial and anti-eukaryotic bacterial polymorphic toxins
Julius Martinkus, Laurent Terradot, Dukas Jurėnas, Eric Cascalès
This paper identifies a bacterial toxin domain with a human CD38-like fold that hydrolyzes NAD+ and NADP+, inhibiting bacterial and eukaryotic growth.