Mary Joseph Mattapallil

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

This paper identifies trehalose monocorynomycolate (TMCM) from C. mast as a stimulator of IL-17-producing γδ T cells at the ocular surface, which protects against corneal infection.

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

The paper shows that T cells entering the eye develop either suppressive regulatory or anergic phenotypes, with both arising from a common precursor, revealing a key checkpoint in ocular immune privilege.

This study shows Laquinimod reduces EAU by targeting AhR-expressing antigen-presenting cells, inhibiting T cell activation and promoting regulatory T cells.

This study shows that vitamin A is needed for initial T cell activation in autoimmune diseases but not for maintaining or expressing effector functions once acquired.