Samuel P. Rowbotham

This study shows that KMT2D's histone methylation activity is essential for proper lung development, with its loss causing hypoplasia and other developmental defects.

The paper validates two genes, Cnot1 and Cdc42bpb, as causes of congenital diaphragmatic hernia in mice using patient-specific variants and shows distinct hernia phenotypes.

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

This study shows that K9me2 and G9a regulate lung progenitor cell activity and regeneration, with their loss altering progenitor dynamics and increasing susceptibility to age-related lung diseases.