Guojia Xie

This study identifies HIRA as an epigenomic regulator of adipose tissue function, showing it promotes adiponectin and lipid metabolism gene expression by facilitating RNA polymerase II pause release.

This study shows that MLL3's tumor suppressor role in breast cancer depends on its adaptor function, not its catalytic activity.

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

This study shows that KMT2D's histone methylation activity is essential for proper lung development, with its loss causing hypoplasia and other developmental defects.

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.