Carla F. Kim

The paper shows that type I interferon primes alveolar epithelial cells for regeneration by enhancing their response to reparative signals from tissue-resident macrophages after viral infection.

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

This paper presents a standardized pipeline to generate airway and alveolar organoids from human bronchoalveolar lavage fluid, enabling disease modeling with minimal starting material and simplified methods.

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

This study identifies Msi2 as a key regulator in lung cancer initiation and progression, showing its dual role in sensitizing cells to transformation and driving tumor growth.

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.

COOBoostR uses extreme gradient boosting to predict tumor tissue or cell-of-origin using chromatin marks and mutation density data, outperforming random forest methods in speed and accuracy.

This study shows that K9me2 and G9a regulate lung progenitor cell activity and regeneration, with their loss altering progenitor dynamics and increasing susceptibility to age-related lung diseases.