Patrizia Pessina

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

The paper identifies ILF2/3 as a regulator of primate cell fate by suppressing Alu element editing, showing its role in preventing aberrant splicing and maintaining epigenetic stability.

The paper profiles RNA content in P-bodies across vertebrate species, showing that RNA sequestration in condensates is linked to cell fate transitions through miRNA-dependent mechanisms.

COOBoostR uses extreme gradient boosting to predict tumor tissue or cell-of-origin using chromatin marks and mutation density data, outperforming random forest methods in speed and accuracy.

This study shows that K9me2 and G9a regulate lung progenitor cell activity and regeneration, with their loss altering progenitor dynamics and increasing susceptibility to age-related lung diseases.