Jordan R. Beach

This study examines how disease-associated MYH11 variants affect SMII filament dynamics and VSMC mechanics through live-cell imaging, revealing distinct functional impacts of K1256del and A1839V variants.

The paper identifies ACK as a regulator of LACL turnover by promoting actin branching to resolve arrested clathrin lattices in Arpc2 KO cells.

This study shows that septins form mechanosensitive networks under the nucleus to protect it from mechanical stress.

The paper investigates how RhoA activation affects septin cytoskeleton structure and finds that local RhoA activation increases septin accumulation independently of anillin.

The paper shows LIM domain proteins like zyxin detect global adhesion tension by recognizing strained actin, while vinculin remains unaffected, revealing a disconnect between molecular and global tension.

This study shows that non-muscle myosin 2A lacking the ACD can co-assemble with existing filaments, indicating the ACD is not required for association with established filaments.

This study identifies lung-resident memory B cells as a key source of allergen-specific IgE in the respiratory tract and shows their role in maintaining allergic asthma.