Ana Rita Amândio

This study identifies a Cadherin switch mechanism that regulates self-organization in gastruloids by linking pluripotency exit and cell differentiation.

The paper uses in-cis mutations to study CTCF site functions in the mouse HoxD cluster, showing their roles in insulation, enhancer-promoter interactions, and TAD border formation.

The paper investigates how regulatory landscapes around the HoxD gene cluster are formed and function, finding that individual sequence deletions have minimal impact on transcription.