Frederik Otzen Bagger

The paper analyzes eccDNA length distributions and breakpoint organization across multiple datasets to show that eccDNA formation is influenced by nucleosome positioning and DNA helix orientation.

This study uses FCCS to assess pathogenic variants in BRCA1 and other proteins, showing its effectiveness in identifying disease-causing mutations.

This paper provides consensus recommendations for standardizing bioinformatics practices in clinical whole genome sequencing to ensure accuracy, reproducibility, and comparability of results.

The paper provides a framework for molecular cancer subtyping that integrates quality control, normalization, batch correction, classification, and reporting, with a use case in breast cancer.

This study benchmarks three plate-based scRNA-seq protocols for high gene detection sensitivity, reproducibility, and cost efficiency in clinical applications.

The paper benchmarks CNV detection tools on WGS and WES data using clinical standards and reference samples, finding that combining multiple tools improves recall but precision remains a challenge.

The paper uses super-resolution microscopy and fluorescence correlation spectroscopy to show that small mRNP granules contain single mRNAs and RNA-binding proteins, suggesting they are mRNA singletons.

SinaPlot is a new visualization tool that effectively represents single observations across multiple classes by combining density and jitter to convey data spread, outliers, and sample size.

The paper measures and compares transcriptional and epigenetic variability across immune cell types and finds neutrophils exhibit higher variability linked to immune pathways and environmental exposure.