Deborah C. I. Goberdhan

This study shows that cofilin overexpression suppresses tau- and Aβ-induced defects in dense-core granule formation and neurodegeneration in Drosophila.

This study shows that Rab11-exosome biogenesis regulators like Chmp5 control Aβ-induced endolysosomal trafficking defects and neurodegeneration in Drosophila.

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

This study shows GAPDH facilitates EV biogenesis and enables efficient siRNA delivery to the brain, reducing huntingtin gene expression in a mouse model.