Author

Wei‐Li Kuan

University of CambridgeORCID 0000-0002-0273-1320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander J. WhitworthiD· 1 shared Alfina A. SpecialeiD· 1 shared André GörgensiD· 1 shared Axel SandvigiD· 1 shared Cláudia C. MendesiD· 1 shared Clément Rey· 1 shared CLIVE G. WILSONiD· 1 shared Deborah C. I. GoberdhaniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Alexander J. WhitworthORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 14, 2026

Cross-platform multi-laboratory screening identifies HUWE1, USP33 and USP20 as negative-regulators of autophagy or mitophagy with relevance to neurodegeneration

Maria Luisa Giudici, Emily Coode, Wing Hei Au…·John Skidmore

The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.

DOI 10.64898/2026.09.07.749806

humanDrosophila

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NeuroscienceNature CommunicationsPeer-reviewedNov 18, 2021

GAPDH controls extracellular vesicle biogenesis and enhances therapeutic potential of EVs in silencing the Huntingtin gene in mice via siRNA delivery

Ghulam Hassan Dar, Cláudia C. Mendes, Wei‐Li Kuan…·Matthew J. A. Wood

This study shows GAPDH facilitates EV biogenesis and enables efficient siRNA delivery to the brain, reducing huntingtin gene expression in a mouse model.

100 citationstop 3%

mousebulk RNA-seq

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NeuroscienceAmerican Journal of Physiology-Cell PhysiologyPeer-reviewedMay 5, 2021

Criticality as a measure of developing proteinopathy in engineered human neural networks

Vibeke Devold Valderhaug, Kristine Heiney, Ola Huse Ramstad…·Ioanna Sandvig

This study examines how inducing alpha-synuclein pathology in engineered human neural networks affects network criticality, revealing subtle changes in network function before overt symptoms appear.

15 citations

humanelectronic health records

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