Digantkumar Gopaldas Chapla

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.

The paper characterizes two GT61 enzymes in Sorghum bicolor, identifies their functions in xylan modification, and identifies a residue critical for sugar donor specificity through structural and biochemical analysis.

This study shows that exofucosylation of T cells enhances their homing and therapeutic efficacy in treating solid tumors and metastases.

The paper constructs an HMO biosynthesis network using multi-omics integration to predict glycosyltransferases and propose candidate genes for HMO synthesis pathways.