Molecular BiologyNature CommunicationsPeer-reviewed
Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment
Zhuoyao Chen, Gamma Chi, Timea Baló…·Alex N. Bullock
The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.
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