Zhuoyao Chen

The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.

This study shows that loss of IVNS1ABP causes a progeroid neuropathy by impairing proteostasis, leading to protein aggregation and lysosomal dysfunction in neuronal cells.

This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.

The paper determines the crystal structure of the KLHL20-DAPK1 complex, revealing the molecular basis of DAPK1 recruitment to the KLHL20 E3 ligase and suggesting a novel target for PROTAC-based drug design.