Author

András Kotschy

ORCID 0000-0002-7675-3864Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alex N. BullockiD· 1 shared András HerneriD· 1 shared Arpad Kiss· 1 shared Beatriz Ralsi MontesiD· 1 shared Gamma ChiiD· 1 shared Steven C. CliffordiD· 1 shared Tibor NovákiD· 1 shared Timea BalóiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Alex N. BullockORCID

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1 paper

Recent·Most cited

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Zhuoyao Chen, Gamma Chi, Timea Baló, Xiangrong Chen, Beatriz Ralsi Montes, Steven C. Clifford, Vincenzo D’Angiolella, Tímea Szabó, Arpad Kiss, Tibor Novák, András Herner, András Kotschy, Alex N. Bullock

The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.

Nature Communications · Apr 2, 2025Peer-reviewedMolecular Biology