Author

Steven C. Clifford

Newcastle UniversityORCID 0000-0003-4893-2184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alex N. BullockiD· 1 shared András HerneriD· 1 shared András KotschyiD· 1 shared Andrew D.J. PearsoniD· 1 shared Andrew S. MooreiD· 1 shared Arpad Kiss· 1 shared Beatriz Ralsi MontesiD· 1 shared Brian A. WalkeriD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alex N. BullockORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedApr 2, 2025

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Zhuoyao Chen, Gamma Chi, Timea Baló…·Alex N. Bullock

The paper identifies how neomorphic KBTBD4 mutations and the drug UM171 recruit HDAC1/2 complexes through structural mimicry, revealing a common mechanism for their degradation.

10 citations

humanprotein structure

𝕏 PostBluesky

GenomicsOncotargetPeer-reviewedDec 6, 2017

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

Elisa Izquierdo, Lina Yuan, Sally L. George…·David González de Castro

The paper develops a targeted sequencing panel for paediatric solid tumours and validates its sensitivity and specificity across various sample types.

21 citations

humanwhole-exome sequencing

𝕏 PostBluesky