Anna Kovilakath

This study shows that knocking out β-galactosylceramidase in human melanoma cells reduces mitochondrial sphingolipids, leading to impaired energy metabolism and bioenergetic insufficiency.

This study investigates the role of SphK1 in adipose thermogenesis and mitochondrial function, finding depot-specific effects on beiging and metabolic outcomes.

This study identifies SPTLC3's role in integrating bile acid-FXR signaling with sphingolipid remodeling in MASLD, showing its dysregulation in human liver and association with disease.

This study shows glucocorticoids induce SphK1 in adipose-derived stem cells, which enhances glucocorticoid signaling and adipose expansion, though SphK1 is not essential for adipogenesis.

This study shows that SphK1, a circadian-regulated gene in adipocytes, affects histone modifiers and disrupts circadian function through altered histone acetylation and HDAC localization.