Hiroki Oota

The paper develops a hiPSC-based framework to study ancestry-related phenotypic variation in the Japanese population, finding no hepatic triglyceride differences despite genetic associations.

This study analyzes 42 genomes from Jomon hunter-gatherers to show they adapted to cold environments through positive selection during the Last Glacial Maximum.

The paper investigates the sex bias in admixture between Jomon hunter-gatherers and continental farmers in modern Japanese genomes, finding a female-biased contribution from continental farmers.

This study examines the functional divergence of vertebrate DSCAM paralogs through evolutionary pressures, revealing distinct selective constraints and positive selection patterns in their intracellular domains.

The paper estimates the demographic history of the Jomon people using complete mitogenomes, revealing an effective population size increase during the Incipient-Initial phase not seen in present-day Japanese populations.

The paper uses next-generation sequencing to assess endogenous DNA preservation in ancient bones by correlating collagen residual ratios with mapping ratios in Jomon remains.

The paper analyzes the genome of a Jomon individual to infer migration patterns into East Asia, finding multiple waves and a coastal route from Southeast Asia.

This paper introduces a new targeted capture method, BDC, using BAC libraries as baits for sequencing large genes, showing it is cost-effective and maintains data quality comparable to commercial kits.

The paper analyzes ancient mitochondrial DNA from Verteba Cave, Ukraine, to study the genetic origins and demographic history of the Tripolye Culture, finding low mtDNA diversity and evidence of demographic expansion during peak occupation.

The paper shows that CYP1B1 polymorphisms influence sexual dimorphism in medaka fish anal fin morphology.