Koichi Hashizume

This study examines the functional divergence of vertebrate DSCAM paralogs through evolutionary pressures, revealing distinct selective constraints and positive selection patterns in their intracellular domains.

The paper uses spatial multi-omics to analyze FCDIIb tissue, revealing cell-type-specific effects of mTOR mutations on metabolic and immune pathways in drug-resistant epilepsy.

This study identifies MEIS1 as a key transcription factor required for the development of Bergmann glia-specific properties in the cerebellum by regulating the expression of BG-specific genes.