Sean M. Gay

Reward-guided inference-time search over the Proteína-Complexa sequence-structure codesign model yields validated binders across 127 targets, kinases and a free carbohydrate, with codesigned sequences outperforming ProteinMPNN redesign.

This study examines the effects of sleep deprivation on synaptic vulnerability across developmental stages in mice, finding heightened sensitivity in juveniles and links to ASD risk.

This study shows that chronic hyperexcitation in cultured neurons triggers homeostatic downscaling and enhances endocannabinoid signaling through coordinated changes in FAAH, anandamide, and CB1.