NeurosciencebioRxivPreprint
Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration ina tauopathy mouse model
Danira Toral-Ríos, Justin M. Long, Jason D. Ulrich…·Steven M. Paul
This study shows that Ch25h/25HC promotes neuroinflammation and neurodegeneration in a tauopathy mouse model by enhancing proinflammatory signaling and impairing sterol synthesis.
DOI 10.1101/2023.09.08.556884