Author

Jinsheng Yu

Washington University in St. LouisORCID 0000-0003-3377-4304Unclaimed ORCID profile · follow to get notified of new preprints

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Jinsheng Yu1 paper

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anil G. CashikariD· 2 shared Danira Toral-RíosiD· 2 shared Steven M. PauliD· 2 shared Brendan P. LuceyiD· 1 shared David M. HoltzmaniD· 1 shared Douglas K. BrubakeriD· 1 shared Jason D. UlrichiD· 1 shared Jee Hyun ParkiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Anil G. CashikarORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintMar 24, 2026

Cross-Species Translation Enhances the Use of Mouse Models for Translatability and Drug Discovery in Late-Onset Alzheimer's Disease

Jee Hyun Park, Jinsheng Yu, Brendan P. Lucey, Douglas K. Brubaker

The paper develops a cross-species translation framework to identify therapeutic targets for late-onset Alzheimer's disease using mouse models and human data.

DOI 10.64898/2026.03.21.713391

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 9, 2023

25-hydroxycholesterol mediates brain cytokine production and neutrophil infiltration in a mouse model of lipopolysaccharide-induced neuroinflammation

Johnathan Romero, Danira Toral-Ríos, Jinsheng Yu…·Anil G. Cashikar

This study shows that 25-hydroxycholesterol mediates sex-specific proinflammatory responses in the brain by promoting microglia and astrocyte activation and neutrophil infiltration in a mouse model of LPS-induced neuroinflammation.

DOI 10.1101/2023.10.09.561598

mouseproteomics

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NeurosciencebioRxivPreprintSep 8, 2023

Microglial 25-hydroxycholesterol mediates neuroinflammation and neurodegeneration ina tauopathy mouse model

Danira Toral-Ríos, Justin M. Long, Jason D. Ulrich…·Steven M. Paul

This study shows that Ch25h/25HC promotes neuroinflammation and neurodegeneration in a tauopathy mouse model by enhancing proinflammatory signaling and impairing sterol synthesis.

DOI 10.1101/2023.09.08.556884

mousebulk RNA-seq

𝕏 PostBluesky