Structural and Computational Analysis of Pseudomonas Aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance
Lalith Perera, Libertad Garcı́a-Villada, Andrea M. Kaminski…·Paul W. Doetsch
The paper analyzes the molecular mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa by solving the gyrase structure and performing MD simulations of wild-type and mutant systems.