Irma H. Lemmens

Dynamic engagement of dual-role regulators by the Sin3 complex

The paper investigates how dual-role regulators interact with the Sin3 complex using structural and functional analyses, revealing mechanisms for transcriptional crosstalk.

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

Missense mutations in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions

The paper investigates missense mutations in PREPL in CMS22 patients, showing they affect non-hydrolytic functions without impairing hydrolase activity.

Expanding the HDAC druggable landscape beyond enzymatic activity

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

Binary Interactome Models of Inner- Versus Outer-Complexome Organization

The paper constructs a high-quality yeast binary interactome map and compares inner- and outer-complexome organization, finding the outer-complexome contains more interactions and exhibits higher functional heterogeneity.

Maximizing binary interactome mapping with a minimal number of assays

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.

A reference map of the human protein interactome

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.