Kyrellos E. Ibrahim

This paper uses a genomic language model to design and optimize a synthetic biosynthetic pathway for producing a non-natural molecule, achieving a 9.4-fold increase in production.

The paper integrates CAD blueprints with diffusion models to explicitly program protein shapes, demonstrating emergent functions through molecular design.

This study develops lentiviral vectors with improved specificity and reduced immune clearance for in vivo CAR T cell generation, showing efficacy in a preclinical model.