Author

Kepler S. Mears

Harvard UniversityORCID 0000-0003-2566-3532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Fernando W. RossineiD· 2 shared Michael BaymiD· 2 shared Shreyas V PaiiD· 2 shared Alexánder RojasiD· 1 shared Amy D. ZamoraiD· 1 shared Audrey J. MuscatoiD· 1 shared Célia SouqueiD· 1 shared Chun‐Cheih ChaoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Fernando W. RossineORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 24, 2026

SOS-mediated prophage induction constrains resistance evolution to DNA-damaging antibiotics

Amy D. Zamora, Shreyas V Pai, Kepler S. Mears…·Michael Baym

This study shows that prophage induction via SOS response limits resistance evolution to DNA-damaging antibiotics by eliminating mutants with high DNA damage.

DOI 10.64898/2026.06.23.733845

bacteria (other)DNA methylation

𝕏 PostBluesky

BioengineeringbioRxivPreprintApr 23, 2025

In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Kepler S. Mears, Kyrellos E. Ibrahim, Peter M. Allen…·Robert T. Manguso

This study develops lentiviral vectors with improved specificity and reduced immune clearance for in vivo CAR T cell generation, showing efficacy in a preclinical model.

2 citations

humanexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 20, 2025

RNA-guided nucleases enable a gene drive of insertion sequences in plasmids

Kepler S. Mears, Fernando W. Rossine, Natalia Quinones‐Olvera…·Michael Baym

The paper demonstrates that RNA-guided nuclease TnpB enables gene drive in plasmids by biasing the inheritance of insertion sequences.

2 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky