Maria S. Ioannou

This study shows ApoE4 impairs astrocyte lipid droplet formation by disrupting endolysosomal function and demonstrates that PCSK9 can restore lipid droplet formation by preventing ApoE4 internalization.

This study shows that glucosylceramide-induced ectosomes transmit pathogenic α-synuclein between neurons in Parkinson's disease.

The paper shows ApoE2 and ApoE3Ch variants protect neurons by removing toxic peroxidated lipids, while ApoE4 worsens lipid-induced damage in rodent models.

This study identifies cell-specific roles of AD risk genes in ROS-induced glial lipid droplet formation and shows how their loss affects Aβ42 toxicity and plaque formation.

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.