Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewed
The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins
M. I. Khalil, Jie Wang, Lexi Vu…·Dohun Pyeon
This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.