The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins
M. I. Khalil, Jie Wang, Lexi Vu, Canchai Yang, C. Yin, Smriti Chadha, Harrison Nabors, Daniel B. Vocelle, Danielle G. May, Rachel J. Chrisopulos, Craig C. Welbon, Li Zhou, Kyle J. Roux, William Charles Spanos, Matthew P. Bernard, , Dohun Pyeon
This study identifies MARCHF8 as a driver of cancer immune evasion by degrading MHC-I proteins and shows its inhibition enhances antitumor immunity and response to immunotherapy.
Proceedings of the National Academy of Sciences · Mar 9, 2026Peer-reviewedCancer Biology