Author

Dantong Zhu

Institute for Systems BiologyORCID 0000-0003-0875-0490Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Dantong Zhu2 papers · National University of Singapore

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alice E. KaneiD· 3 shared David A. SinclairiD· 3 shared Patrick T. GriffiniD· 3 shared Amber L. MuelleriD· 1 shared Brady A. Samuelson· 1 shared Charlotte Duesing· 1 shared Christian DieneriD· 1 shared Christopher A. PettyiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMolecular Biology

Alice E. KaneORCID

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Author profile →

3 papers

Recent·Most cited

DNA methylation signatures of frailty beyond age: a longitudinal study of female and male mice

Dantong Zhu, Shyleen Frost, Patrick T. Griffin, Maeve S. McNamara, David A. Sinclair, Alice E. Kane

This study identifies DNA methylation signatures associated with frailty in mice, distinguishing age-independent and -dependent mechanisms and revealing sex-specific patterns.

bioRxiv · Dec 16, 2025 · PreprintMolecular Biology

Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice

Dantong Zhu, Judy Z. Wu, Patrick T. Griffin, Brady A. Samuelson, David A. Sinclair, Alice E. Kane

This study identifies sex-specific metabolite biomarkers of frailty in aging mice using longitudinal metabolomics and machine learning.

npj Aging · May 23, 2025Peer-reviewedBiochemistry

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

Alice E. Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew W. Arnold, Jien Li, Joao Amorim, Christian Diener, Dantong Zhu, Sarah Jayne Mitchell, Patrick T. Griffin, Xiao Tian, Christopher A. Petty, Ryan J. Conway, Katie Walsh, Lukas M. Shelerud, , David A. Sinclair

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology