Author

Matthew W. Arnold

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alice E. KaneiD· 2 shared Amber L. MuelleriD· 2 shared David A. SinclairiD· 2 shared James R. MitchelliD· 2 shared Jien LiiD· 2 shared Patrick T. GriffiniD· 2 shared Sarah Jayne MitchelliD· 2 shared Xiao TianiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersPharmacology & Toxicology

Alice E. KaneORCID

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2 papers

Recent·Most cited

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

Alice E. Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew W. Arnold, Jien Li, Joao Amorim, Christian Diener, Dantong Zhu, Sarah Jayne Mitchell, Patrick T. Griffin, Xiao Tian, Christopher A. Petty, Ryan J. Conway, Katie Walsh, Lukas M. Shelerud, , David A. Sinclair

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology

TIME-Seq Enables Scalable and Inexpensive Epigenetic Age Predictions

Patrick T. Griffin, Alice E. Kane, Alexandre Trapp, Jien Li, Matthew W. Arnold, Jesse R. Poganik, Maeve S. McNamara, Margarita V. Meer, Noah Hoffman, João Pedro Amorim, Xiao Tian, Michael Robert MacArthur, Sarah Jayne Mitchell, Amber L. Mueller, Colleen Carmody, , David A. Sinclair

The paper introduces TIME-Seq, a low-cost method for epigenetic age prediction, and validates it on mouse and human samples, showing improved scalability and accuracy.

bioRxiv · Oct 25, 2021 · PreprintGenomics