Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
Alice E. Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew W. Arnold, Jien Li, Joao Amorim, Christian Diener, Dantong Zhu, Sarah Jayne Mitchell, Patrick T. Griffin, Xiao Tian, Christopher A. Petty, Ryan J. Conway, Katie Walsh, Lukas M. Shelerud, , David A. Sinclair
This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.
bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology