Rob van der Kant

This paper designs IL2 muteins with enhanced Treg or CD8 T cell specificity and improved production by predicting mutations using SolubiS and testing their functional and structural properties.

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

This paper analyzes amyloid polymorphism structure to explain disease-related stability and polymorphic bias, identifying conserved structural frameworks and templating interactions that influence cellular vulnerability.