Evelien H.S. Schut

This paper develops a CRISPR/Cas9-based method to reduce dopamine receptor levels in multiple rodent species, enabling comparative studies of neural mechanisms.

The paper uses the Object Space Task to show Ehmt1 +/- mice have reduced episodic-like memory and exploration but enhanced semantic-like memory, with semantic features better for genotype classification.

This study shows that acute stress in female mice leads to long-lasting changes in dopaminergic system function and behavior.