Developmental BiologybioRxivPreprint
Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger
Jinglin Zhu, Sin Man Lam, Leilei Yang…·Xun Huang
The paper identifies nhr-114 and spin-4 as suppressors of seip-1 embryonic lethality in C. elegans, showing that reducing phosphatidylcholine synthesis suppresses lethality but worsens lipid droplet abnormalities.
DOI 10.1101/2022.04.10.487805