Guanghou Shui

Multiomics Characterization Identifies S1P-secreting USSHigh Skeletal Muscle Stem Cells as Essential Drivers of Niche Remodeling and Muscle Regeneration

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

Plasma membrane PI4P recruits SNAP47 to mediate SNARE-dependent AMPAR exocytosis during synaptic potentiation

The paper identifies PI4P's role in recruiting SNAP47 to facilitate SNARE-dependent AMPAR exocytosis during synaptic potentiation.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger

The paper identifies nhr-114 and spin-4 as suppressors of seip-1 embryonic lethality in C. elegans, showing that reducing phosphatidylcholine synthesis suppresses lethality but worsens lipid droplet abnormalities.

Assisted reproduction causes intrauterus growth restriction by disrupting placental lipid metabolism

This study shows that IVF disrupts placental lipid metabolism, leading to intrauterus growth restriction and low birth weight by altering gene expression and imprinting status.