Molecular BiologybioRxivPreprint
Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.
Batuhan Yenilmez, Mark Kelly, Guofang Zhang…·Michael Czech
The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.
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