Mark Kelly

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

This study shows that MCT1 in hepatic stellate cells promotes collagen expression in NASH, while hepatocyte MCT1 does not significantly affect fibrosis.

This study shows that targeting both DGAT2 in hepatocytes and FASN in stellate cells reduces NASH in mice more effectively than targeting either gene alone.

This study identifies de novo lipogenesis as a critical source of fatty acids for autophagosome membrane dynamics in adipocytes, showing that Fasn deficiency impairs autophagy and p62 degradation.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

This study shows that apoE-deficient mice have a reduced transcriptional response in visceral fat to high-fat diet, linked to increased metabolic efficiency and resistance to obesity.